Table 3. GADD45a promoter SNP rs581000 genotypes in Chicago and Spanish cohorts.
| Chicago study | GG | GC | CC | Frequency (GC+CC) | Odds Ratio (CI) | p value |
| Controls (n = 368) | 215 | 134 | 19 | 0.42 | ||
| Severe sepsis (n = 208) | 139 | 59 | 10 | 0.33 | 0.70 (0.49–0.95) | 0.05 |
| Sepsis+ALI (n = 114) | 76 | 31 | 7 | 0.33 | 0.70 (0.45–1.09) | 0.12 |
| AA Chicago study | GG | GC | CC | Frequency (GC+CC) | Odds Ratio (CI) | p value |
| Controls (n = 182) | 68 | 99 | 15 | 0.63 | ||
| Severe sepsis (n = 71) | 36 | 28 | 7 | 0.49 | 0.58 (0.33–1.01) | 0.05 |
| Sepsis+ALI (n = 40) | 24 | 12 | 4 | 0.40 | 0.40 (0.20–0.80) | 0.009 |
| EA Chicago study | GG | GC | CC | Frequency (GC+CC) | Odds Ratio (CI) | p value |
| Controls (n = 186) | 147 | 35 | 4 | 0.21 | ||
| Severe sepsis (n = 137) | 103 | 31 | 3 | 0.25 | 1.24 (0.74–2.10) | 0.41 |
| Sepsis+ALI (n = 74) | 52 | 19 | 3 | 0.30 | 1.59 (0.87–2.94) | 0.14 |
| Spanish study | GG | GC | CC | Frequency (GC+CC) | Odds Ratio (CI) | p value |
| Controls (n = 95) | 44 | 50 | 1 | 0.54 | ||
| Severe sepsis (n = 80) | 64 | 14 | 2 | 0.20 | 0.22 (0.11–0.43) | 5x10−6 |
| Sepsis+ALI (n = 66) | 54 | 10 | 2 | 0.18 | 0.19 (0.09–0.40) | 6x10−6 |
AA represents African American and EA represents European American in the Chicago study.