Figure 4. Effect of late phase BSE-CD treatment on hepatic fibrosis of liver tissue from mice that had been infected with S. japonicum.

Mice were infected with 20±2 cercariae, Treatment with BSE-CD or placebo from week 7 until week 11. (A) Mice were killed, and liver tissues were fixed in formalin and stained with Masson trichrome or (B) anti-SMA antibody. Collagen deposition and the α-SMA positive areas were quantified as shown on the right hand panel, respectively. All data are expressed as mean ± SEM (n = 8 for each group). *P<0.05 versus corresponding infected mice or the cyclodextrin (280 mg/kg) group.