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. 2014 Jun 18;9(6):e100242. doi: 10.1371/journal.pone.0100242

Figure 9. CL vs DDR relationship.

Figure 9

Panel A: a representative example of hyperbolic relationship (R = 0.99) between CL vs DDR measured during application of Iva. Black dots refer to beats recorded at the steady state (s.s.) in NT; empty red dots refer to beats recorded right after Iva application; filled red dots refer to beats recorded at the s.s. in Iva. Panel B: CL vs DDR hyperbolic relationship (R = 0.98) measured from APs of the current injection experiment reported in Figure 8A. Panels C and D: steady state CL vs DDR relationships for Iva and Rya (C), and ACh (D) were always well fitted by linear regressions, whose slopes are reported in figure. Panels E and F: the histograms summarize changes induced on the slope of CL vs DDR by Iva and Rya (E) and by ACh (F). Statistics: paired t-test. p<0.05 vs NT (*); p<0.1 vs NT (#); p<0.1 vs Iva (§);