Table 3.

Mean 3-month IOP reductions with currently available fixed-combination glaucoma medications

Fixed combination	N	Hours after dosing	Mean ± SD absolute IOP change from baselinea (mmHg)	Mean ± SD IOP change from baselinea (%)
Dorzolamide/timolol64	114	0	−7.7±4.2	−27.4±13.1
	112	2	−9.0±4.3	−32.7±12.9
Dorzolamide/timolol70	151	0	−4.2±3.3	−16.3±12.5
	151	2	−5.4±3.1	−21.6±12.3
Dorzolamide/timolol74	120	0	−3.6±3.0	−13.8±11.1
	119	2	−5.0±3.5	−19.7±12.9
	116	8	−3.7±3.4	−14.9±13.2
Brinzolamide/timolol75	171	0	−8.3±3.8	30.6c
	171	2	−8.7±3.9	33.7c
Brimonidine/timolol66	385	0	−7.0b	NA
	385	2	−7.5b	NA
	385	7	−5.5b	NA
Brimonidine/timolol73	385	0	−7.0b	NA
	NA	2	−7.5b	NA
	NA	7	−5.5b	NA
Latanoprost/timolol67	NA	Diurnald	−3.6b,c,e	NA
Latanoprost/timolol68	129	Diurnalf	−10.2c	NA
Latanoprost/timolol71	170	Diurnalf	−10.0c	NA
Latanoprost/timolol72	140	Diurnald	−2.6c,e	NA
Bimatoprost/timolol65	533	0	−9.2±3.7	NA
	NA	2	−7.8±4.0	NA
	NA	8	−7.4±4.0	NA
Travoprost/timolol69	151	0	−8.7±3.2	−34±12
	151	2	−7.8±3.0	−33±11
	151	8	−7.4±3.0	−32±11
Brinzolamide/brimonidine54	196	0	−6.7c	−24.6b
	194	2	−8.3c	−32.2b
	194	7	−5.4c	−22.1b
Brinzolamide/brimonidine53	189	0	−7.1c	−26.4b
	189	2	−8.8c	−34.8b
	189	7	−5.7c	−24.1b

Notes:

^aNotes: When available;

^bapproximate values (estimated from graphical data);

^ccalculated means from values stated in article text or tables;

^ddiurnal IOP was calculated as the mean of IOP measures at 8 am, 10 am, and 4 pm;

^eIOP assessed at 13 weeks;

^fmean IOP at 8 am, 10 am, and 4 pm or the mean of non-missing IOP measurements if a measurement was missing.

Abbreviations: IOP, intraocular pressure; NA, not available; SD, standard deviation.