Fig. 1. Effects of intranasally administered vanadium on locomotor activity.
Male C57 black mice were intranasally administered 182 µg of V2O5 in 50 µL of de-ionized water three times a week for one month. The vehicle control animals were administered de-ionized water. Locomotor activity was measured using an automated VersaMax locomotor activity monitor before the termination of the study. A, Representative moving tracks of mice. B, Total vertical movement. C, Total horizontal movement. D, Total distance travelled. E, Total movement time. F, Total rest time. The vehicle-treated group served as the control. Data are in percent control and represent mean ± S.E.M. from at least five animals per group. Asterisks (*, p < 0.05; **, p<0.001) indicate significant differences between treatment and the control group.
