Fig. 5. Loss of glomerular TH neurons in olfactory lobes following intranasally administered vanadium.

Male C57 black mice were intranasally administered 182 µg of V₂O₅ in 50 µL of de-ionized water three times a week as described in methods. The vehicle control animals were administered de-ionized water. At the end of treatment, animals were intracardially perfused and TH neurons were detected in the glomerular layer of the olfactory lobe by immunohistochemistry. (A) Representative 2× pictures of TH neurons in the glomerular layer of the olfactory lobe of control and vanadium-treated mice. (B) Representative 30× pictures of TH neurons in the glomerular layer of the olfactory lobe of control and vanadium-treated mice. (C) Representative 60× pictures of TH neurons in the glomerular layer of the olfactory lobe of control and vanadium-treated mice.