Table 3.

Two-year and median survival stratified by treatment and analytic methodology.

	Two-year survival (95% CI)		Median survival (95% CI)
	Primary surgery	Primary chemotherapy	Primary surgery	Primary chemotherapy
All Patients
Observational	0.56 (0.55-0.75)	0.36 (0.34-0.38)	28.8 (27.7-29.8)	15.8 (15.1-17.1)
PS reweighted (matched)	0.49 (0.46-0.51)	0.40 (0.38-0.43)	23.5 (21.6-24.6)	18.5 (17.4-19.5)
PS reweighted (IPTW)	0.54 (0.53-0.55)	0.45 (0.44-0.47)	27.2 (26.0-28.2)	21.0 (20.1-21.5)
Instrumental variable
<Median value of IV	0.49 (0.48-0.51)		23.8 (22.8-24.8)
≥Median value of IV		0.50 (0.48-0.52)		24.1 (23.2-25.5)
Intended Treatment
Observational	0.64 (0.63-0.66)	0.58 (0.55-0.62)	34.7 (33.1-36.1)	28.1 (26.2-30.5)
PS reweighted (matched)	0.63 (0.60-0.67)	0.59 (0.55-0.62)	32.7 (30.4-35.6)	28.2 (26.2-30.8)
PS reweighted (IPTW)	0.64 (0.63-0.66)	0.58 (0.56-0.59)	34.7 (33.1-36.1)	28.1 (27.1-28.8)
Instrumental variable
<Median value of IV	0.62 (0.61-0.64)		32.5 (31.3-34.8)
≥Median value of IV		0.64 (0.62-0.66)		35.9 (33.5-37.6)