Table 4. Potential drug interactions with sofosbuvir that may warrant dose or regimen adjustmenta1.
| Concurrent medication | Drug interaction | Commentary |
| Anticonvulsant | ||
| Carbamazepine Phenytoin Phenobarbital Oxcarbazepine |
Decreased sofosbuvir and GS-331007 plasma concentrations | Coadministration is not recommended. |
| Antimycobacterial | ||
| Rifabutin Rifampin Rifapentine |
Decreased sofosbuvir and GS-331007 plasma concentrations | Coadministration is not recommended. Note that sofosbuvir should be avoided with rifampin. |
| Herbal products | ||
| Hypericum perforatum (St. John’s wort) | Decreased sofosbuvir and GS-331007 plasma concentrations | Coadministration should be avoided. |
| HIV protease inhibitor | ||
| Tipranavir/ritonavir | Decreased sofosbuvir and GS-331007 plasma concentrations | Coadministration is not recommended. |
a
Interactions based on predictions or drug interaction studies.