Table 6. Dose adjustment for coadministered ribavirin^a based on cardiac or hemoglobin status¹.

Laboratory values	Consider ribavirin dose reduction to 600 mg/day	Consider discontinuationb
Hemoglobin in patients without cardiac disease	< 10 g/dL	< 8.5 g/dL
Hemoglobin in patients with a history of stable cardiac disease	Decreased hemoglobin ≥ 2 g/dL in any 4-wk treatment period	< 12 g/dL despite 4 wk of dose reduction

^aFor complete information, refer to the ribavirin prescribing information.

^bAfter ribavirin is stopped due to laboratory or clinical reasons, an attempt can be made to restart it at 600 mg titrated to 800 mg; ribavirin should not be restarted at the higher recommended starting doses (1,000 or 1,200 mg).