Table 2.
Frequency distribution of the TopBP1 genotypes/alleles in cases and controls, and the risk of endometrial cancer
| Variables | Cases (%)/Controls (%) | OR (95 % CI)a | p* |
|---|---|---|---|
| rs115160714 | |||
| C/C | 112 (92.6)/548 (98.6) | 1.00 (ref.) | 0.0003 |
| C/T | 8 (6.6)/7 (1.2) | 5.59 (1.96–15.91) | 0.21 |
| T/T | 1 (0.8)/1 (0.2) | 4.89 (0.30–79.23) | |
| C | 232 (99.2)/1103 (99.2) | 1.00 (ref.) | |
| T | 10 (7.4)/9 (0.8) | 5.28 (2.12–13.14) | 0.0001 |
| p- trendb | 0.0003 | ||
| C/T or T/T vs. C/Cc | 5.50 (2.05–14.74) | 0.0001 | |
| C/T or C/C vs. T/Td | 4.62 (0.29–74.46) | 0.28 | |
* p value for additive models
aAdjusted for age
bTesting additive genetic model (Cochran-Armitage test for trend)
cTesting dominant genetic model
dTesting recessive genetic model