Table 1.
Starting daily dose of study drug based on dose of previous opioid treatment
| Previous opioid dose (mg) | Starting dose (mg) | |||||
|---|---|---|---|---|---|---|
| Oxycodone CR | Durotep® MT Patcha | Fentos® Tapea | OneDuro® Patcha | Morphine SR | Tapentadol ER | Morphine SRb |
| ≥15 to ≤20 | 2.1 (0.3 mg/day) | 1 (0.3 mg/day) | 0.84 (0.3 mg/day) | ≥20 to ≤30 | 100 | 30 |
| >20 to ≤30 | – | – | – | >30 to ≤40 | 150 | 40c |
| >30 to ≤40 | 4.2 (0.6 mg/day) | 2 (0.6 mg/day) | 1.7 (0.6 mg/day) | >40 to ≤60 | 200 | 60 |
| >40 to ≤60 | 6.3 (1.2 mg/day) | 3 (1.2 mg/day) | 2.54 (1.2 mg/day) | >60 to ≤90 | 300 | 90 |
| >60 to ≤80 | 8.4 (1.8 mg/day) | 4 (1.8 mg/day) | 3.4 (1.8 mg/day) | >90 to ≤120 | 400 | 120 |
CR controlled release, ER extended release, SR sustained release, – indicates absence of doses converted
aPrevious opioid dose (mg) of Durotep® MT Patch, Fentos® Tape, and OneDuro® Patch indicates fentanyl content per patch or tape. Nominal release rate (mg/day) of fentanyl is shown in parentheses
bStarting doses of morphine SR shown are for patients who were previously taking oxycodone CR, the Durotep® MT Patch, Fentos® Tape, or the OneDuro® Patch. Patients who were previously taking morphine SR continued on the same dose
cAlthough the dose calculated based on the equianalgesic ratio was 45 mg, a 40-mg dose was used because a 45-mg dose is not available