Fig. 9.

TRPA1 pore helix and selectivity filter. a Alignment of mouse TRPA1 and TRPVs at putative pore helices (gray) and selectivity filters (yellow). L906 of TRPA1 and T633 of TRPV1 are indicated in red. b Alignment of pore helices and selectivity filters for TRPA1 from selected animal species. The conserved PXLS motif in terrestrial vertebrates is highlighted in gray and the phenylalanine in frog and methionines in insects and nematode at the position equivalent to mouse L906 are highlighted in yellow. GenBank accession numbers are indicated in square brackets