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. 2014 Jul;28(7):3249–3260. doi: 10.1096/fj.13-245142

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Figure 8. — Proposed model of stretch-induced Rho signaling regulation at focal adhesions. HTV-relevant cyclic stretch activates Src/FAK-dependent phosphorylation of paxillin at Tyr³¹ and Tyr¹¹⁸ and MEK-dependent phosphorylation/activation of p44/42 MAPK and MAPK association with paxillin. Paxillin–p44/42 MAPK then recruits and activates GEF-H1 via p44-MAPK-mediated Thr⁶⁷⁸ phosphorylation. CS-induced GEF-H1–paxillin association requires paxillin LD4 domain. As a result, stretch-induced formation of paxillin/p44/42-MAPK/GEF-H1 signalosome stimulates local Rho signaling, leading to activation of MLC phosphorylation, actomyosin contraction, and increased endothelial permeability.