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. 2013 Oct 27;466(7):1391–1409. doi: 10.1007/s00424-013-1382-1

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© The Author(s) 2013

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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Fig. 10 — Downregulation of TMEM16A has no effect on nonselective cation current (I _NSC). I _NSC was evoked by dialyses of isolated SMCs with 400 μM GTPγS from the patch pipette. SMCs were held at −50 mV and the GTPγS-evoked I _NSC current reached a peak 3 to 7 min after breakthrough to the whole-cell configuration (indicated by an arrow in a). This I _NSC was inhibited by 10 μM GdCl₃. a Representative current trace at holding potential −50 mV recorded on SMC isolated from an artery transfected with Tmem16a-siRNA. b The averaged current–voltage relationships for baseline membrane currents recorded immediately after breaking through the patch membrane and the peak I _NSC recorded in SMCs isolated from nontransfected arteries (n = 6), arteries transfected with eGFP-siRNA (n = 6), and arteries transfected with Tmem16a-siRNA (n = 8)