Fig. 12.

Downregulation of TMEM16A reduced the amplitude but not the frequency of NA-induced vasomotion in isolated rat mesenteric small arteries in vitro. a Representative recordings of NA-induced vasomotion in nontransfected and TMEM16A-downregulated arteries. b The distribution of vasomotion amplitudes over oscillation frequencies 0–0.5 Hz. ***P < 0.001 for arteries transfected with mutated siRNA (n = 6) vs. TMEM16A-downregulated arteries (n = 6). ⁺⁺ P < 0.01 for nontransfected arteries (n = 9) vs. TMEM16A-downregulated arteries. ^‡‡ P < 0.01 for eGFP-siRNA transfected arteries (n = 3) vs. TMEM16A-downregulated arteries