Fig. 8.

TMEM16A-downregulated arteries can depolarize to the same extent as eGFP-siRNA-transfected arteries but they have reduced contractility. Membrane depolarization to NA and tone production in Tmem16a-siRNA arteries was lower in comparison with eGFP-siRNA-transfected arteries. Resting membrane potential and depolarization to 60 mM K⁺ were unchanged, but force production to elevated extracellular K⁺ is also lower in Tmem16a-siRNA arteries compared to eGFP-siRNA arteries (n = 6–7). *P < 0.05, **P < 0.01