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. 2013 Dec 13;14(12):R135. doi: 10.1186/gb-2013-14-12-r135

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Copyright © 2013 Mehta et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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DNA damage caused by cisplatin treatment. Normal human dermal fibroblasts were treated with cisplatin and the extent of DNA damage and survival were monitored. Cells were treated for 4 hours with 25 μM cisplatin or 0.05% DMSO (control). γH2AX foci (A) and protein levels (D) increased in cisplatin-treated cells compared to their control counterparts. Annexin V staining (B) and FACS (C) were used to identify the percentage of cells undergoing apoptosis. ** indicates P = 0.001 NS: non-significant.