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. 2013 Aug 30;15(4):R100. doi: 10.1186/ar4280

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Copyright © 2013 Jiang et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Network derived from Ingenuity Pathway Analysis software of children who achieved CRM status using MTX + Et (A) or MTX alone (B) compared with healthy controls. Network analysis is from PBMC (A) and granulocytes (B). Note the prominence of HNF4α as a hub in both networks. Genes shown in red show higher expression in patients compared with controls, and those shown in green show lower expression. CRM, clinical remission on medication; ET, etanercept; MTX, methotrexate; PBMC, peripheral blood mononuclear cells.