Table 2.

Laboratory tests performed prior to treatment of an adult living HIV

HIV serology: ELISA on two different samples with confirmation by Western blot of HIV1 (HIV2 if epidemiological context relevant)

CD4/CD8 T-cell count

Plasma HIV-RNA (viral load)

Genotypic testing for HIV drug resistance (reverse transcriptase, protease) and determination of the HIV-1 subtype (integrase resistance testing and testing of HIV tropism are not recommended at this stage)

HLA-B*5701 screening

Blood cell count with platelet count

ALT/AST, γGT, alkaline phosphatases, total and conjugated bilirubin

Blood creatinine and estimation of glomerular filtration rate (MDRD or CKD-EPI equation)

Fasting blood glucose

Blood phosphate

Fasting lipid profile: total cholesterol, triglycerides, LDL and HDL

Testing for proteinuria (urine dipstick) or determination of the protein/creatinine ratio

Markers of viral hepatitis B: HBs antigen, anti-HBs and anti-HBc antibodies

Serological testing for viral hepatitis C

Serological testing for viral hepatitis A (IgG)

Serological testing for syphilis (Treponema pallidum hemagglutination assay, Venereal Disease Research Laboratory test)

Serological testing for toxoplasmosis

CMV serology testing

IFN-gamma release assay (QuantiFERON or T-SPOT.TB) for detection of latent tuberculosis

If CD4 T-cell count <200/mm3 or person from an area where tuberculosis is endemic: chest X-ray

If CD4 T-cell count <100/mm3: cryptococcal antigen assay, blood CMV PCR test, and fundus examination (if CMV serology positive)

In women who have not had a gynaecological examination for one year, examination with a cervical screening test is recommended.

In men who have sex with men and in people living with HIV who have a history of human papillomavirus lesions, a proctological examination should be proposed to screen for precancerous lesions of the anus.