Table 3.

Summary of gastric LPMC T_RM cells and PBMC T_EM (CD4⁺ and CD8⁺) responses between children and the elderly to adults.

Cytokine	Stim	PBMC		LPMC		PBMC		LPMC
		CD8+ TEM		CDS+ TRM		CD4+ TEM		CD4+ TRM
		Cha	Elb	Ch	El	Ch	El	Ch	El
IL-2	Med
	SEB
	α-CD3/CD28c								*
IFN-γ	Med							*
	SEB
	α-CD3/CD28								*
MIP-1β	Med		*,d
	SEB		*
	α-CD3/CD28		*
TNF-α	Med							*	*
	SEB								**
	α-CD3/CD28		*						**
IL-17A	Med
	SEB
	α-CD3/CD28
CD107a	Med			*
	SEB		*
	α-CD3/CD28		**

LPMC CD8⁺ and CD4⁺ T_RM and PBMC T_EM responses (IL-2, IFN-γ, MIP-1β, TNF-α, IL-17A, and CD107a) to stimulation by two mitogens (SEB and anti-CD3/CD28) were determined and compared between children (Ch) or elderly (El) to adults (children vs. adult and elderly vs. adult). Significant differences are shown in highlighted colors as determined by Mann–Whitney test. Adults: n = 8; children: n = 5; elderly: n = 7. Empty (white) cells indicate non-significant differences between children or elderly vs. adults as determined by Mann–Whitney tests.

^a Children; ^bElderly; ^cAnti-CD3/CD28 beads; ^dLight green color = significant in cytokine production compared to *p < 0.05; *p < 0.005.