Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 19;5:96. doi: 10.3389/fendo.2014.00096

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Sewell and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Applications of iPSC technology. Skin fibroblast-derived iPSCs can produce thyroid follicles. These cells can be used for (A) cell-based therapy, (B) disease modeling, and (C) drug discovery. (A) Based on the demonstrated success of ESCs in rescuing thyroid ablated mice, iPSCs derived thyroid follicles have incredible potential as a cell replacement therapy for a variety of thyroid maladies. (B) iPSC lines with genotypes characteristic of varied genetically based thyroid diseases could provide an avenue to study disease mechanisms as well as a screening system for evaluating pharmaceutical and recombinant approaches aimed at treating those diseases. (C) iPSCs derived thyroid follicles would enable easy quantification of drug effects on follicle structure and function.