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. 2014 Jun 19;5:93. doi: 10.3389/fendo.2014.00093

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Copyright © 2014 Elphick and Mirabeau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Alignment of known orthologous peptides from (A) bilaterian NPY/NPF, (B) bilaterian Cholecystokinin/Gastrin (CCK), and (C) bilaterian Luqin/RYamide families. The names of deuterostomian and protostomian peptides are shaded in pink and blue, respectively. The C-terminal amide groups are represented by an “a” at the end of aligned sequences. Skow Luqin is from Ref. (7), Spur Luqin is from Ref. (75), and Tcas Luqin/RYamide is from Ref. (76). The Lottia gigantea sequences are from Ref. (4), the Capitella teleta sequences are from Ref. (5), and other sequences are from Ref. (8). For vertebrate sequences, only one peptide from each precursor is shown in the alignment. Genbank (GI) or JGI IDs of all precursor sequences are listed below: (A) Alignment of bilaterian NPY/F-type peptides: Hsap_NPY, Hsap_PYY, and Hsap_PAHO; Homo sapiens Neuropeptide Y, Peptide Tyrosine tyrosine, and Pancreatic polypeptide precursors (GI:189273, GI:300068955, and GI:35589); Pmar_NPY, Petromyzon marinus Neuropeptide Y precursor (GI:57231270); Bflo, Branchiostoma floridae NPY-like precursor (GI:260829184); Skow, Saccoglossus kowalevskii NPY-like precursor (GI:585716458); Ctel1-2, Capitella teleta NPF precursors (GI:161315271, JGI:204022); Lgig, Lottia gigantea NPF precursor (GI:163562021); Dpul, Daphnia pulex NPF precursor (GI:168841503); Dmel, Drosophila melanogaster NPF precursor (GI:442619467). (B) Alignment of bilaterian Cholecystokinin/Sulfakinin-type peptides: Hsap, Homo sapiens CCK precursor (GI:84040232); Drer, Danio rerio CCK-like precursor (GI:42490839); Pmar, Petromyzon marinus CCK-like precursor (GI:299891581); Cint, Ciona intestinalis CCK-like (Cionin) precursor (GI:296983); Skow1-2, Saccoglossus kowalevskii CCK-like precursors (GI:585688033, GI:187061456); Spur, Strongylocentrotus purpuratus CCK-like precursor (GI:390355380); Ctel, Capitella teleta Sulfakinin (SK)-type precursor (GI:161296032); Lgig, Lottia gigantean SK-type precursor (GI:163526260); Dpul, Daphnia pulex SK-type precursor (JGI:242979); Dmel, Drosophila melanogaster SK-type precursor (GI:386765036). (C) Alignment of bilaterian Luqin-type peptides: in addition to the luqin sequences, which are followed by a dibasic cleavage site (CS), the sequences of a conserved cysteine-containing C-terminal domain of the precursor proteins are also shown. The residues connecting the two domains are not represented. Skow, Saccoglossus kowalevskii Luqin-like precursor (GI:187205184); Spur, Strongylocentrotus purpuratus Luqin-type precursor (GI:390331827); Apom, Alvinella pompejana Luqin-type precursor (GI:223786475), Lgig, Lottia gigantea, Luqin-type precursor (GI:163510328); Dpul, Daphnia pulex, RYamide-type precursor (JGI:251691); Tcas, Tribolium castaneum, RYamide-type precursor (GI:347807413); Isca, Ixodes scapularis RYamide-type precursor (GI:156462907).