Fig. 3.

Clone frequency distribution of HTLV-1-infected T cells in a representative subject (Patient 1) with non-malignant HTLV-1 infection and a representative case (Patient 2) of ATLL. Upper panels depict the number of cells detected in each clone in a sample of genomic DNA from peripheral blood mononuclear cells, in descending order of clone abundance. In the inset pie charts, the size of each sector depicts the relative abundance of the respective clone; the solid black sector denotes a large number of low-abundance clones. Lower panels show the cumulative fraction of the proviral load constituted by the infected T-cell clones. The oligoclonality index, OCI, is defined [72] as OCI = A/(A + B).