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. 2014 Jun 1;10(6):576–587. doi: 10.7150/ijbs.8479

Figure 1.

Figure 1

Basic mechanism of androgen action. Testosterone (T) or adrenal androgens (AA) are converted to DHT in CaP cells. Ligand activation induces a conformational change and nuclear translocation of AR. Within the nucleus, AR binds AREs in target genes to regulate their transcription and modulate CaP cell behavior. Pre-receptor level ADT interferes with AR ligand production. Receptor level ADT impedes AR-ligand interaction. Post-receptor level ADT exploits AR-dependent action downstream of AR for therapeutic intervention.