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Expression of chondrocyte and osteoblast markers and signaling molecules in Col2a1/Sox9 knock-in mutant embryos. Sections of limb buds of E16.5 wild-type and mutant embryos are hybridized with Col2a1, Col10a1, Bsp, Op, Oc, Sox9, and Runx2 probes (A); and Fgfr3, Ihh, Patched, Pthrp, and PPR probes (B).
