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Rescue of Sox9 heterozygous mice with Col2a1/Sox9 knock-in mutant mice. (A) Appearance of 14-day-old mice. (B) Skeletons of newborn mice stained with alcian blue followed by alizarin red. In Sox9wt/-; Sox9 knock-in (KI) double mutants, the chondrodysplasia is partially corrected. Alcian blue staining of humerus shows the reduction of width of the hypertrophic zone (the bars) in Sox9wt/-; Sox9 knock-in (KI) double mutants, compared with that in Sox9wt/-.
