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. 2014 Jun 19;5:95. doi: 10.3389/fendo.2014.00095

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Copyright © 2014 Hiriart, Sanchez-Soto, Diaz-Garcia, Castanares, Avitia, Velasco, Mas-Oliva, Macias-Silva, González-Villalpando, Delgado-Coello, Sosa-Garrocho, Vidaltamayo and Fuentes-Silva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MS rats show increased insulin binding to plasmatic proteins. (A) Western blot from plasma of control rats (lane 1, 2) and MS rats (3, 4, 5) that were previously separated using different Amicon centrifugal filters and immunoprecipitated with an insulin receptor (alpha-IR) in a native gel, stained with an anti-insulin antibody. Observe that insulin is present in different molecular weight bands, Section “Materials and Methods.” (B) Rats with metabolic syndrome (MS) show increased insulin levels when compared to control rats (C). (C) MS rats display higher insulin levels in the plasmatic fraction containing proteins above 30 kDa, suggesting higher insulin binding to plasmatic proteins. Bars represent mean ± SEM of control (n = 12) and MS rats (n = 7), *p < 0.05 and ***p < 0.0001.