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. 2014 Jun 19;5:95. doi: 10.3389/fendo.2014.00095

Figure 9.

Figure 9

Plasma SIR is detected in healthy and diabetic patients. (A) Fasting plasma glucose levels and (B) insulin, from healthy subjects (H) and patients (P) that present hyperglycemia and hyperinsulinemia. (C) Representative Western blots of alpha-IR immunoprecipitated plasma from healthy subjects and hyperglycemic–hyperinsulinemic patients. Note that alpha-IR immunoblotting appears in two bands (close to the expected size for α-IR monomer: 135 kDa, and a fragment around 75 kDa) of a SDS-PAGE gel. (D) A tendency of higher SIR levels is observed in the plasma of hyperglycemic–hyperinsulinemic patients. SIR levels were determined by densitometry of the experiments depicted in (D) and normalized with respect to the average level of healthy subjects. (E,F) Show the correlation between the normalized SIR levels and the plasmatic insulin, which resulted significant for patients. Bars represent mean ± SEM of healthy subjects (N = 9) and hyperglycemic–hyperinsulinemic patients (N = 17), *p < 0.05.