. Author manuscript; available in PMC: 2014 Dec 1.

Published in final edited form as: Crit Care Med. 2013 Dec;41(12):e439–e446. doi: 10.1097/CCM.0b013e318298ad3a

Table 1.

Pulmonary arterial pressure, gas exchange, ventilatory parameters, variables of acid base balance as well as coagulation and rhATIII levels

Variable	Group	BL	6h	12 h	24 h	48 h
MPAP	control	20 ± 1	26 ± 1^*	30 ± 1^*	31 ± 1^*	34 ± 4^*
(mm Hg)	rhATIII	19 ± 1	24 ± 1^*	26 ± 1^*^†	25 ± 1^*^†	28 ± 2^*
PaO₂/FiO₂	control	506 ± 16	503 ± 45	431 ± 34	160 ± 28^*	83 ± 6^*
(mmHg)	rhATIII	540 ± 18	554 ± 61	574 ± 71^†	358 ± 65^*^†	199 ± 48^*^†
Peak pressure	control	19 ± 1	19 ± 1	21 ± 1	31 ± 2^*	40 ± 2^*
(cmH₂O)	rhATIII	20 ± 1	19 ± 1	21 ± 1	24 ± 3^†	31 ± 4^*^†
Plateau pressure	control	17 ± 1	16 ± 0	18 ± 1	28 ± 2^*	39 ± 3^*
(cmH₂O)	rhATIII	17 ± 0	16 ± 1	18 ± 1	19 ± 2^†	29 ± 4^*^†
Respiratory rate	control	20 ± 0	21 ± 0	19 ± 1	23 ± 2	38 ± 3^*
(breaths·min⁻¹)	rhATIII	20 ± 0	20 ± 1	20 ± 0	20 ± 0	28 ± 5^*^†
ACT	control	141 ± 6	/	157 ± 8	143 ± 10	136 ± 8
(sec)	rhATIII	142 ± 9	/	145 ± 8	152 ± 10	143 ± 11
PT	control	78 ± 4	/	94 ± 5^*	86 ± 5	99 ± 7^*
(sec)	rhATIII	75 ± 7	/	93 ± 5^*	86 ± 5	86 ± 6
aPTT	control	110 ± 4	/	117 ± 5	128 ± 8	122 ± 7
(sec)	rhATIII	117 ± 3	/	121 ± 7	119 ± 5	117 ± 4
Protein (plasma)	control	6.2 ± 0.2	4.8 ± 0.1^*	4.5 ± 0.1^*	4.0 ± 0.0^*	3.7 ± 0.2^*
g·dL⁻¹	rhATIII	6.1 ± 0.2	5.1 ± 0.2^*	4.9 ± 0.1^*^†	4.6 ± 0.1^*^†	4.9 ± 0.2^*^†
Protein (lymph)	control	4.1 ± 0.2	2.7 ± 0.2^*	2.6 ± 0.2^*	2.2 ± 0.1^*	1.8 ± 0.2^*
g·dL⁻¹	rhATIII	4.5 ± 0.2	3.1 ± 0.1^*	3.3 ± 0.2^*^†	2.9 ± 0.1^*^†	2.9 ± 0.4^*^†
NOx plasma	control	2.4 ± 0.4	8.0 ± 2.0^*	10.9±1.7^*	5.2 ± 1.3	10.9±1.9^*
(µM)	rhATIII	2.6 ± 0.4	4.7 ± 0.5	5.3 ± 0.6^†	2.0 ± 0.8	1.8 ± 0.6^†
AT plasma	control	100 ± 0	83 ± 6^*	72 ± 4^*	72 ± 13^*	71 ± 8^*
(% of BL)	rhATIII	100 ± 0	113 ± 15^†	110 ± 4^†	101 ± 5^†	106 ± 5^†

, p < .05 vs. BL;

^†

, p < .05 vs. control; each group n = 6

ACT, activated clotting time; aPTT, activated partial thromboplastin time; AT, antithrombin; BE, base excess; BL, baseline; FiO₂, inspiratory oxygen fraction; MPAP, mean pulmonary arterial pressure; PaCO₂, partial pressure of carbon dioxide; PaO₂, partial pressure of oxygen; pH, potentia hydrogenii; PT, prothrombin time; rhATIII, recombinant human antithrombin III