Table 4.

Significant activation clusters of the Activation Likelihood Estimate (ALE) analyses.

Contrast	Region	Volume(mm3)	x	y	z	ALE(x103)	Number of studies/Foci per cluster
Task > Control (minimum cluster size 304mm3)	L pre-SMA	2560	−2	18	46	19.3	4/10
	R pre-SMA		6	12	58	8.8
	R insula; anterior part	1304	30	24	2	17.05	4/5
	R insula; anterior part		40	18	−4	14.4
	L insula; anterior part	768	−32	18	−2	14.7	3/3
	R putamen	448	22	8	2	15.2	2/2
	R inferior parietal lobule (PFop)	432	56	−16	24	14.7	2/2
	L middle frontal gyrus	432	−28	−4	52	11.2	1/1
	R posterior cingulate gyrus	312	4	−36	34	11.6	2/2
	R inferior parietal lobule (hIP2)	312	42	−42	46	10.7	2/2
	R anterior occipital sulcus (hOC5)	304	46	−66	4	12.1	2/2
	L inferior frontal gyrus; p. opercularis	304	−56	10	22	10.4	2/2
Hard > Easy (minimum cluster size 320mm3)	R pre-SMA	4040	2	18	46	24.7	9/10
	R insula; anterior part	3560	38	20	0	20.1	9/9
	R inferior frontal gyrus; p. triangularis		50	22	12	9.7
	R pre-central gyrus	2328	42	4	32	25.4	6/6
	R angular gyrus; hIP3	2168	28	−60	46	14	6/7
	R superior occipital gyrus; SPL		24	−72	42	10.5
	L inferior frontal gyrus; p. opercularis	1904	−40	8	28	11.4	5/6
	L pre-central gyrus		−46	−2	38	11
	L pre-central gyrus		−38	−2	26	7.9
	L insula; anterior part	1840	−32	22	4	17.5	6/6
	R pre-central gyrus	1448	32	−6	54	15.3	4/5
	L superior frontal gyrus	1008	−22	4	60	11.6	3/4
	L superior frontal gyrus		−24	−10	58	9
	L superior parietal lobule (SPL)	760	−26	−66	54	10.5	2/3
	R inferior parietal lobule (hIP3)	680	42	−46	52	12.3	2/3
	L inferior parietal lobule (hIP3)	552	−30	−50	44	12.4	2/2
	L middle occipital gyrus (hOC3v)	520	−30	−90	10	11.4	1/1
	R middle occipital gyrus	440	32	−84	10	11.3	2/2
	L calcarine gyrus	432	−10	−96	−4	12	2/2
	R calcarine gyrus	360	16	−98	4	11.5	2/2
	R middle frontal gyrus	360	32	46	16	10.6	2/2
	L superior occipital gyrus	320	−22	−76	30	9	2/2
Reward Anticipation > Control (minimum cluster size 288mm3)	R caudate nucleus	15208	12	10	−10	33	8/48
	L putamen		−12	8	−10	26.5
	L caudate nucleus		−6	2	0	23
	R pallidum		10	4	−2	17.7
	R rectal gyrus		22	12	−16	17.2
	L thalamus		0	−18	10	16
	R amygdala		22	2	−20	15
	L amygdala		−14	2	−16	14.3
	R substantia nigra	1664	8	−16	−16	19.6	2/5
	L mammillary body		−2	−16	−18	14.1
	R inferior frontal gyrus; p. orbitalis	1568	36	22	−22	14.4	4/5
	R inferior frontal gyrus; p. orbitalis		42	22	−14	13
	R superior medial gyrus	1040	6	46	30	15.2	3/4
	L insula; anterior part	1000	−38	14	−16	14.5	2/4
	L cerebellum; lobule VII crus II	448	−22	−74	−42	13.8	1/2
	L anterior cingulate gyrus	440	0	42	12	10	2/3
	R superior medial frontal gyrus		6	52	16	9.3

Several clusters had multiple peak ALE values and are reported in ALE as subclusters. Note that these do not have a volume estimate as they are part of the main cluster.