TABLE 2. Functional Environmental Sensors on MSCs and NPCs.
| Receptor | Ligand | Stem Cellsa | Described Functionb | References |
|---|---|---|---|---|
| MHC-I/II | MSCs/NPCs | Not known | Multiple refs. | |
| CD80/CD86/CD40 | MSCs/NPCs | Not known | Multiple refs. | |
| CD49d (VLA-4) | VCAM-1 | NPCs | Homing/adhesion | (Guzman et al., 2008; Pluchino et al., 2005) |
| P-selectin | P-selectin glycoprotein ligand (PSGL)-1 | MSCs | Homing/adhesion and migration | (Ruster et al., 2006) |
| CXCR4 | SDF-1α/CXCL12 | MSCs/NPCs | Migration | (Carbajal et al., 2010; Corti et al., 2005; Imitola et al., 2004b; Mueller et al., 2006; Wang et al., 2008) |
| CD44 | HA | Role in interaction with endothelial cells and extravasation | (Qian et al., 2012; Rampon et al., 2008; Zhu et al., 2006) | |
| CCR2 | MCP-1/CCL2 | NPCs | Transendothelial recruitment | (Andres et al., 2011) |
| CXCR1 and CXCR5 | IL-8/CXCL8 and CXCL13 | NPCs | Role in interaction with endothelial cells and extravasation | (Weiss et al., 2010) |
| CX3CR1 | Fractalkine/CX3CL1 | MSCs | Trafficking | (Ji et al., 2004; Zhu et al., 2009) |
| HGF | HGFR/cMet | MSCs | Migration and recruitment | (Neuss et al., 2004) |
| TLR | TLR agonists | MSCs | Migration and recruitment, immune modulation; secretion of cytokines and chemokines | (Liotta et al., 2008; Romieu-Mourez et al., 2009; Tomchuck et al., 2008) |
a
Evidence from bone marrow-derived MSCs only are quoted.
b
Function described in stem cell immune interactions.