Table 2.
Clinical data before development of microalbuminuria and during observation period in 277 patients followed from onset of type 1 diabetes. Values are numbers (percentages) unless stated otherwise
| Clinical details | No microalbuminuria (n=198) | Microalbuminuria (n=79) | P value | ||
|---|---|---|---|---|---|
| Before microalbuminuria | |||||
| Mean (SEM) height (cm) | 174.9 | (0.7) | 173.5 | (1.0) | 0.27 |
| Mean (SEM) weight (kg) | 75.4 | (0.9) | 73.4 | (1.3) | 0.23 |
| Smoking status: | 0.86 | ||||
| Smoker | 88 | (44) | 38 | (48) | |
| Non-smoker | 67 | (34) | 25 | (32) | |
| Former smoker | 43 | (22) | 16 | (20) | |
| Antihypertensive treatment | 28 | (14) | 49 | (62) | <0.001 |
| No antihypertensive treatment | 170 | (86) | 30 | (38) | <0.001 |
| Retinopathy: | |||||
| Absent | 80 | (40) | 4 | (5) | <0.001 |
| Simplex | 115 | (58) | 61 | (77) | <0.001 |
| Proliferative | 3 | (2) | 14 | (18) | <0.001 |
| Follow up | |||||
| Mean (SEM) systolic blood pressure (mm Hg) | 127 | (0.9) | 129 | (1.8) | 0.31 |
| Mean (SEM) diastolic blood pressure (mm Hg) | 78 | (0.5) | 80 | (0.9) | 0.10 |
| Geometric mean (95% CI) urinary albumin excretion rate (mg/24 h) | 8 | (8 to 9) | 14 | (12 to 16) | <0.001 |
| Mean (SEM) haemoglobin A1c concentration (%) | 8.3 | (0.1) | 9.1 | (0.1) | <0.001 |
| Mean (SEM) serum cholesterol concentration (mM) | 5.2 | (0.1) | 5.5 | (0.2) | 0.09 |
| Mean (SEM) serum creatinine concentration (μM) | 78 | (0.7) | 76 | (1.6) | 0.26 |
| Insulin dose/body weight (IU/kg) | 0.56 | (0.01) | 0.56 | (0.02) | 0.95 |