Table II.
Summary of Pharmacokinetic Parameters for Acyclovir Following Oral Valacyclovir Administration (15 mg/kg)
| Parameter | Mean ± SD | Median (range) | |
|---|---|---|---|
| Cmax | (uM) | 18.8 ± 7 | 17.1 (7.9 – 40.3) |
| Tmax | (min) | 128.7 ± 57 | 120 (60 – 250) |
| AUC∞ | (uM•min) | 4106 ± 1519 | 3934 (1672 – 8510) |
| CL | (ml/min/kg) | 11.4 ± 4.4 | 10.7 (5.2 – 23.4) |
| t ½ | (min) | 87.5 ± 29 | 80 (41.3 – 173) |
| VC | (L/kg) | 1.34 ± 0.65 | 1.23 (.33 – 3.3) |
| Tau | (min) | 23 ± 12.4 | 25.8 (1.2 – 70) |
| Renal CL | (ml/min/kg) | 3.03 ± 2.2 | 2.31 (0.35 – 8.21) |
VC= volume of distribution; CL=kel•VC