Scheme 1.
Synthesis of quinoxalines. Reagents and conditions: a) R2COCO2H, CH3OH, RT, 30 min; b) POCl3, 100 °C, 1 h; c) N-methylpiperazine, mw, 120 °C, or N-methylpiperazine, EtOAc, mw, 160 °C, 15 min.
Synthesis of quinoxalines. Reagents and conditions: a) R2COCO2H, CH3OH, RT, 30 min; b) POCl3, 100 °C, 1 h; c) N-methylpiperazine, mw, 120 °C, or N-methylpiperazine, EtOAc, mw, 160 °C, 15 min.