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. 2013 Aug 12;57(12):2185–2194. doi: 10.1002/mnfr.201300216

Figure 1.

Figure 1

Effect of the GPX4c718t SNP in HUVEC and fatty acid pretreatment on monocyte adhesion. HUVECs genotyped for GPX4c718t (CC or TT) were grown to confluence under Se replete or Se deficient conditions (+Se and −Se) and challenged with TNF-α and the number of adhering monocytes was assayed. Cells were either pretreated with no fatty acid (A) or had prior pretreatment with linoleic acid (B), ARA (C), or docosahexanoic acid (D) at 10 μM for 48 h. All values are expressed as a percentage (± SEM) of the value obtained for the level of monocyte adhesion to cells of the CC genotype after TNF-α challenge in the absence of Se and fatty acid. Statistical analysis was carried out by four-way ANOVA on the log-transformed data followed by post hoc t-tests (*p < 0.05, and **p < 0.01).