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Effect of the GPX4 718 SNP and Se availability on cell viability. Genotyped HUVECs (CC or TT at GPX4 718) were grown for 4 days in M199 medium with 10% FCS in the presence or absence of 40 nM Se. Cell viability was measured after 4 h treatment with 0.3 mM TBH and is shown as a percentage of untreated CC cells grown in the absence of Se. Values shown are means ± SEM. Student's t-test was used to test for significant differences (*p < 0.05, **p < 0.01, ***p < 0.001).
