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Flow diagram representing prospective trials investigating lapatinib among patients with metastatic breast cancer (A) prior to development of brain metastases [81], (B) immediately following the diagnosis of newly diagnosed brain metastases [20], or (C) following progression of disease following WBRT [21].
Abbreviations: C, capecitabine; CNS, central nervous system; L, lapatinib; TTP, time to progression of brain metastases; WBRT, whole brain radiation therapy.
