Table 2.

Summary of proteins analyzed by Western blot and mass spectrometry. Candidate stringency means that the abundance was increased by 1.2 fold (normalized ratio of treated/untreated protein abundance) in one experiment and increased in at least one other independent experiment (complete list in table S4). Increased or decreased by Western blot denotes changes that are statistically significant or trend level as shown in Figures 2 and 3. Complete table of all proteins measured in the mass spectrometry (MS) 5-hour screen and 48-hour mass spectrometry study appear in tables S1 and S2, respectively.

Protein	Haloperidol 5 hours in culture MS Screen	Haloperidol 4 hours in culture Western blot	Haloperidol 48 hours in culture MS	Haloperidol 24 hours in culture Western blot	Haloperidol 24 hours in vivo Western blot
RpS6 Ribosomal Protein S6	Increased	Increased	Increased (Candidate stringency)	Increased	Not tested
eEF2 eukaryotic Elongation Factor 2	Increased	Increased	Variable	Not tested	Not tested
ARMS (Kidins220) Ankyrin Repeat-Rich Membrane-Spanning Protein	Not detected	Not tested	Increased (Candidate stringency)	Increased	Increased
MAP2 Microtubule-associated protein 2	Increased	Not tested	Increased (Candidate stringency)	Increased	Increased
GSK3β Glycogen synthase kinase 3 beta	Not detected	Not tested	Unchanged	Decreased	Not tested
Clathrin	Unchanged (Clathrin heavy chain 1	Unchanged	Increased (Clathrin heavy chain 1 (unchanged to increased) Clathrin light chain (increased, candidate stringency)	Not tested	Not tested