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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Mar 27;34(6):1272–1280. doi: 10.1161/ATVBAHA.113.303346

Figure 3.

Figure 3

Nicotinic acid activates human TRPV1 with higher sensitivity. (A) Representative current trace recorded from an inside-out patch exposed to capsaicin and nicotinic acid. (B) Current traces recorded at different temperatures in the presence of 0.13 mM nicotinic acid. (C) Heat-dependent activation in the absence and presence of 0.13 mM nicotinic acid. Dotted lines indicate the baseline current and the channel current. Arrows indicate the activation threshold temperature. (D) Comparison of activation threshold temperatures. n = 4 for 0.13 mM nicotinic acid application and 12 for control condition, respectively. ***, p < 0.001.