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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Mar 27;34(6):1272–1280. doi: 10.1161/ATVBAHA.113.303346

Figure 7.

Figure 7

Nicotinic acid rapidly permeates to the intracellular side. (A) No TRPV1 activation by extracellular nicotinic acid in whole-cell recordings. n = 4. (B) Representative pH imaging recording with a nicotinic acid (pH 7.4) concentration ladder applied in sequence, followed by a high potassium solution with nigericin (pH 7.0). (C&D) Amplitude (C) or time constant (D) of intracellular pH change (pHi) is plotted against the nicotinic acid concentration and fitted to an exponential function. n = 3 each.