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. 2014 Mar 21;44(6):1799–1805. doi: 10.3892/ijo.2014.2355

Figure 3.

Figure 3.

Kaplan-Meier curves for disease-free survival (DFS), disease-specific survival (DSS) and overall survival (OS) in patients with HPV-positive oropharyngeal squamous cell carcinoma (OSCC) with known MHC class I expression, where HCA-2 and HC-10 are two antibodies against HLA class I (the human MHC class I). (A) DFS stratified for HCA-2 intensity; (B) DSS stratified for HCA-2 intensity; (C) OS stratified for HCA-2 intensity; (D) DFS stratified for HC-10 intensity; (E) DSS stratified for HC-10 intensity; and (F) OS stratified for HC-10 intensity. HPVDNA+ OSCC with absent HLA class I intensity had a significant better clinical outcome than tumors with strong HLA class I intensity, while weak intensity staining presented an intermediate survival (HCA-2: DFS p<0.001; DSS p=0.060; OS p=0.022; HC-10: DFS p=0.003; DSS p=0.021; and OS p=0.009, with the log-rank test). Notably, the difference observed in the HCA-2 DSS analysis did not reach significance, although the trend was similar. From Näsman et al (46), with permission from the publisher.