Figure 4.

Inhibitory effect of i.p. injection of atorvastatin, celecoxib or tipifarnib alone or in combination on the growth of subcutaneous Panc-1 tumors in SCID mice. Female SCID mice were injected subcutaneously with Panc-1 cells (2×10⁶ cells/0.1 ml) suspended in 50% Matrigel and RPMI medium. Injections of drug were started in mice after they had a tumor (0.6–1.0 cm wide and 0.6–1.0 cm long). The mice (6/group) received daily i.p. injections of vehicle (see below) or atorvastatin (ATOR; 2 μg/g body weight), celecoxib (CEL; 2 μg/g) or tipifarnib (TIP; 0.8 μg/g) alone or in combination. Each value is the mean ± SE. The linear trend in tumor growth for the atorvastatin + celecoxib + tipifarnib group was significantly different from that for any other group (p=0.0034).