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. 2014 Apr 16;8(1):211–217. doi: 10.3892/ol.2014.2071

Figure 8.

Figure 8

Cisplatin-induced apoptosis in melanoma cells with overexpression or knockdown of angiopoietin-like 4 (ANGPTL4) and/or aldolase A (ALDOA). (A) WM-115 cells: TUNEL assays were performed in control cells, cells stably transfected with empty pcDNA3 vector, cells overexpressing ANGPTL4, cells stably expressing ALDOA-shRNA, and cells overexpressing ANGPTL4 plus stably expressing ALDOA-shRNA. (B) WM-266-4 cells: TUNEL assays were performed in control cells, cells stably transduced with scramble control shRNA, cells stably expressing ANGPTL4-shRNA, cells overexpressing ALDOA, and cells stably expressing ANGPTL4-shRNA plus overexpressing ALDOA. The cells were treated with 10 nM of cisplatin for 8 h. Cell apoptosis rates at 4 and 8 h were shown as the percentage of TUNEL positive cells in total cells. WM-115 cells: *P<0.05, compared with Control and Vector. WM-266-4 cells: *P<0.05, compared with Control and Scramble.