Table I.
Univariate and multivariate analysis of prognostic factors (n=268).
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
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|
|
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| Variables | n (%) | P-value | HR (95% CI) | P-value | HR (95% CI) |
| Gender | 0.0003 | 1.72 (1.278–2.314) | 0.577 | 1.106 (0.776–1.577) | |
| Male | 186 (69) | ||||
| Female | 82 (31) | ||||
| Age, years | 0.51 | 0.92 (0.703–1.192) | |||
| >66 | 137 (51) | ||||
| <66 | 131 (49) | ||||
| Smoking status | 1.2×10−7 | 2.23 (1.659–3.409) | 0.0009 | 1.86 (1.290–2.675) | |
| Never | 87 (32) | ||||
| Ever | 181 (68) | ||||
| PS | 4.1×10−5 | 2.02 (1.442–2.822) | 5.6×10−6 | 2.21 (1.564–3.106) | |
| 0–1 | 213 (79) | ||||
| 2–3 | 55 (21) | ||||
| Histology | 0.0091 | 1.59 (1.123–2.261) | |||
| Ad | 220 (82) | ||||
| Non-Ad | 48 (18) | ||||
| Relapse following surgery | 0.0017 | 1.77 (1.238–2.519) | 1.48×10−5 | 2.28 (1.571–3.317) | |
| Yes | 49 (18) | ||||
| No | 219 (82) | ||||
| Number of metastatic organs | 0.0460 | 1.32 (1.005–1.732) | |||
| 1 | 161 (60) | ||||
| ≥2 | 107 (40) | ||||
| Metastatic sites | |||||
| Intra-thoracic organs | 0.0007 | 0.607 (0.456–0.810) | 0.0009 | 0.593 (0.435–0.808) | |
| Yes | 185 (69) | ||||
| No | 83 (31) | ||||
| Abdominal organs | 2.6×10−5 | 2.07 (1.474–3.649) | 0.0006 | 1.88 (1.311–2.689) | |
| Yes | 55 (21) | ||||
| No | 213 (79) | ||||
| Brain | 0.48 | 1.13 (0.807–1.584) | |||
| Yes | 55 (21) | ||||
| No | 213 (79) | ||||
| Bone | 0.0592 | 1.38 (0.997–1.899) | |||
| Yes | 58 (22) | ||||
| No | 210 (78) | ||||
| Lymph nodes (distant) | 0.6 | 1.12 (0.741–1.684) | |||
| Yes | 29 (11) | ||||
| No | 239 (89) | ||||
Ad, adenocarcinoma; HR, hazard ratio; CI, confidence interval; PS, performance status.