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. 2014 Jun 19;10(6):e1003687. doi: 10.1371/journal.pcbi.1003687

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© 2014 Javaheri et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Parameter values in the acceptance range of objective function for case 1, when there is no penalty term in the model. Most of parameters are scattered in this case, which means that there are many solutions to the optimization problem. (B) Parameter values in acceptance range of objective function for case 2, when penalty terms added to the objective function. In this case, besides and , most of the parameter values are not scattered much.

Inline graphic — (A) Parameter values in the acceptance range of objective function for case 1, when there is no penalty term in the model. Most of parameters are scattered in this case, which means that there are many solutions to the optimization problem. (B) Parameter values in acceptance range of objective function for case 2, when penalty terms added to the objective function. In this case, besides and , most of the parameter values are not scattered much.