Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 19;10(6):e1003655. doi: 10.1371/journal.pcbi.1003655

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Monte Carlo simulations show that our expanded model produces ESN numbers and spacings that match with experimentally determined values. (B) The distributions for the number and spacing of ESNs, including the minimum/maximum and variances of the distributions, are all very similar between model and experiment. For the top graphs, the y-axis shows the number of midlines with the given number of ESNs. For the bottom graphs, the y-axis shows the number of times a given ESN spacing occurs. (C) Schematic showing the intra- and inter-cellular interactions between Notch and Delta. The squiggle arrow represents cis-inhibition of Notch by Delta. Note that for clarity only two cells are shown, but the interactions extend over a linear array of cells. (D) The general form of the ordinary differential equations of our expanded model for Cell , with addition of a Notch activity gradient term indicated in red. (E–F) Shown are the equilibrium values of Delta after a typical run of our expanded model in comparison with the original core model [12], [20].

Inline graphic — (A) Monte Carlo simulations show that our expanded model produces ESN numbers and spacings that match with experimentally determined values. (B) The distributions for the number and spacing of ESNs, including the minimum/maximum and variances of the distributions, are all very similar between model and experiment. For the top graphs, the y-axis shows the number of midlines with the given number of ESNs. For the bottom graphs, the y-axis shows the number of times a given ESN spacing occurs. (C) Schematic showing the intra- and inter-cellular interactions between Notch and Delta. The squiggle arrow represents cis-inhibition of Notch by Delta. Note that for clarity only two cells are shown, but the interactions extend over a linear array of cells. (D) The general form of the ordinary differential equations of our expanded model for Cell , with addition of a Notch activity gradient term indicated in red. (E–F) Shown are the equilibrium values of Delta after a typical run of our expanded model in comparison with the original core model [12], [20].