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. 2014 Jun 19;10(6):e1003655. doi: 10.1371/journal.pcbi.1003655

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© 2014 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Representative embryo for miR-124 titration experiments. (B) Magnified region of the embryo in (A) shows adjacent ESNs; DAPI staining shows pairs of small nuclei belonging to the ESN pairs. (C–D) Comparison of the distribution of ESN counts and spacing between miR-124 titration experiments and our model. Based on this data and our previous results [33], [34], we propose that the Notch decay rate, , is modulated by miR-124.

Inline graphic — (A) Representative embryo for miR-124 titration experiments. (B) Magnified region of the embryo in (A) shows adjacent ESNs; DAPI staining shows pairs of small nuclei belonging to the ESN pairs. (C–D) Comparison of the distribution of ESN counts and spacing between miR-124 titration experiments and our model. Based on this data and our previous results [33], [34], we propose that the Notch decay rate, , is modulated by miR-124.