Table 2. Number of pool-based GWAS SNPs selected for replication by EOC subtype.
Subtype | SNP selection methoda | # SNPs chosen | # SNPs successfully genotyped | # Independent tests of association |
---|---|---|---|---|
Mucinous | Cluster | 48 | 43 | 43 |
Singleton | 13 | 13 | ||
| ||||
Endometrioid/Clear cell | Cluster | 46 | 43 | 42 |
Singleton | 13 | 12 | ||
| ||||
LMP Serous | Cluster | 41 | 40 | 43 |
Singleton | 13 | 13 | ||
| ||||
Invasive Serous | Cluster | 24 | 24 | 15 |
Singleton | 0 | 0 | ||
| ||||
Total | 198 | 188 | -- |
Cluster refers to SNPs chosen based on P-value and their being in linkage disequilibrium (LD) with other GWAS SNPs having a small P-value. Singleton refers to SNPs not in LD with other GWAS SNPs, and chosen based on P-value alone. See Methods for details.