Table II.
Studies on the effect of androgen administration on CR.
| Androgen | Dose | Species/tissue | Key findings | Reference |
|---|---|---|---|---|
| DHEAS | 0.01 mg/ml 0.1 mg/ml |
Human In vitro: HCF derived from term pregnancy |
↑ IL-8 in conditioned medium ↑ IL receptor in HCF |
Kanayama et al. (1998) |
| DHEAS | 200 mg | Human In vivo: term pregnant women (>38 weeks) |
↑ Bishop score ↑ Collagenase activity |
Mochizuki et al. 1978a, b |
| DHEAS | 200 mg | Human In vivo: term pregnant women (38–42 weeks) |
↑ Bishop score ↑ Collagenase activity ↑ E2 in maternal serum |
Mochizuki and Maruo (1985) |
| DHEAS | 50–100 mg | Human In vivo: term pregnant women (38–42 weeks) |
↑ Bishop score ↓ Time to delivery No side effects |
Mochizuki et al. 1978a, b |
| DHEAS | 100 mg | Human In vivo: term pregnant multiparous and nulliparous women (>38 weeks) |
↑ Bishop score ↓ Duration of labour in nulliparous women ↓ Time to delivery in nulliparous No side effects |
Sasaki et al. (1982) |
| DHEAS | 50–200 mg | Human In vivo: term pregnant singleton and twin pregnancies (>39 weeks) |
↑ Bishop score (higher correlation of Bishop score with twin pregnancies) ↑ E2 levels in maternal serum (higher correlation of E2 levels with twin pregnancies) No change in E1, E3 levels in maternal serum. |
Takahashi et al. (1984) |
| DHEAS | 1 μM | Rabbit In vitro: CCs derived from term pregnancy |
↑ Collagenase levels No effect of E2 or DHEA treatment |
Sakyo et al. (1986) |
| DHEAS | 1 μM | Rabbit In vitro: CCs derived from term pregnancy |
↑ Collagenase levels No effect on collagen levels |
Sakyo et al. (1987) |
| DHEAS | 10 mg | Rabbit In vivo: term pregnancy |
↑ Collagenase activity ↓ Collagen content Combined DHEAS + IL-8 (100 ng) treatment-induced neutrophil infiltration Combined treatment produced maximal decrease in collagen content |
Maradny et al. (1996) |
| DHEAS | 100 mg | Rat In vivo: term pregnancy (day 16) |
↓ Collagen content ↑ Collagenase activity |
Yamashita et al. (1991) |
| DHEA | 0.01 mg/ml 0.1 mg/ml |
Human In vitro: HCF derived from term pregnancy |
Increase of IL-8 in conditioned medium Increase of IL receptor in HCF |
Kanayama et al. (1998) |
| DHT | 2 mg | Rat In vivo: term pregnancy (15 day) |
↓ Cervical resistance ↓ Proteoglycan mRNA Flutamide treatment (10 mg) ↑ Cervical resistance ↑ Proteoglycan mRNA |
Ji et al. (2008) |
DHEAS, dehydroepiandrosterone sulphate; DHT, dihydrotestosterone; HCF, human cervical fibroblast; CCs, cervical cells.