Table 5. Cytochrome P450 and b5 genes differentially expressed in the SP (R) strain relative to the susceptible SMK (S) strain of Aedes aegypti.
| Female | Male | Larva | Strain or Population | |||||||||||||||||||
| Gene name | Transcript ID | R/S | P | R/S | P | R/S | P | A | B | C | D | E | F | G | H | I | J | K | L | |||
| CYP9M6 | AAEL001312 | 23.96 | * | 6.72 | 31.87 | * | 4.60 | 26.08 | * | 2.50 | ||||||||||||
| CYP9M5 | AAEL001288 | 16.64 | * | 6.03 | 13.25 | * | 3.75 | 10.97 | * | 2.32 | ↑ | |||||||||||
| CYP6Z8 | AAEL009131 | 6.47 | * | 3.57 | 4.57 | * | 4.01 | 0.89 | 0.39 | ↑ | ||||||||||||
| CYP6Z7 | AAEL009130 | 6.36 | * | 4.31 | 8.11 | * | 3.26 | 8.88 | * | 2.42 | ||||||||||||
| CYP325E3 | AAEL000338 | 5.88 | * | 4.30 | 2.65 | 0.62 | 1.19 | 0.30 | ||||||||||||||
| CYP9M4 | AAEL001320 | 5.86 | * | 3.47 | 9.18 | * | 6.58 | 7.55 | * | 2.39 | ||||||||||||
| CYP6M6 | AAEL009128 | 5.63 | * | 2.49 | 2.50 | 3.68 | 2.22 | 2.06 | ↑ | ↑ | ||||||||||||
| CYP6BB2 | AAEL014893 | 5.41 | * | 4.15 | 3.94 | * | 5.10 | 2.89 | 1.73 | ↑ | ↑ | ↑ | ↑ | ↑ | ||||||||
| CYP6CB2 | AAEL002872 | 4.02 | * | 3.44 | ND | ND | 0.07 | 0.39 | ↑ | |||||||||||||
| CYP6F3 | AAEL014684 | 3.69 | * | 2.77 | 14.76 | * | 2.62 | 1.79 | 0.80 | ↑ | ||||||||||||
| Cytochrome b5 | AAEL014935 | 3.65 | * | 2.14 | 6.42 | * | 3.88 | 3.98 | * | 2.74 | ||||||||||||
| CYP6F2 | AAEL014678 | 3.52 | * | 2.15 | 11.02 | * | 3.54 | 2.49 | 1.08 | |||||||||||||
| CYP4C50 | AAEL008017 | 3.44 | * | 4.02 | 13.63 | * | 4.34 | 2.07 | 0.44 | |||||||||||||
| CYP6CB2 | AAEL014924 | 3.27 | * | 3.56 | 3.21 | 0.73 | 1.80 | 0.89 | ↑ | ↑ | ||||||||||||
| CYP6N12 | AAEL009124 | 3.24 | * | 2.61 | 2.05 | 3.22 | 2.16 | 1.19 | ↑ | |||||||||||||
| CYP9J28 | AAEL014617 | 3.24 | * | 3.21 | 1.54 | 3.35 | 1.56 | 0.53 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ||||||||
| CYP9J26 | AAEL014609 | 3.52 | 1.78 | 4.20 | * | 3.02 | 3.91 | * | 2.51 | ↑ | ↑ | ↑ | ||||||||||
| CYP9J27v2 | AAEL014607 | 3.69 | 1.96 | 3.95 | * | 2.53 | 7.19 | * | 2.62 | ↑ | ↑ | ↑ | ||||||||||
| CYP6Z6 | AAEL009123 | 2.48 | 3.50 | 3.14 | * | 2.82 | 3.28 | * | 3.78 | ↑ | ↑ | ↑ | ↑ | |||||||||
| CYP6AA5 | AAEL012492 | 2.62 | 4.06 | 3.02 | * | 6.68 | 3.16 | 1.85 | ↑ | |||||||||||||
| CYP9J27v1 | AAEL014616 | 2.74 | 2.20 | 2.64 | 3.14 | 5.28 | * | 2.54 | ↑ | ↑ | ↑ | ↑ | ||||||||||
| CYP9J20v1 | AAEL006814 | 1.08 | 0.09 | 1.93 | 4.01 | 4.27 | * | 2.04 | ||||||||||||||
| CYP9J10v2 | AAEL014614 | 1.68 | 2.48 | 2.00 | 3.88 | 3.09 | * | 3.86 | ↑ | ↑ | ↑ | |||||||||||
Asterisks indicate a relative change (R/S) >3-fold and a P-value (negative log10 scale) >2.
The symbol (↑) indicates over expression of the gene reported in the resistant population or the following strains:
A, Cayman (females) [57]; B, Cuba (females) [57]; C, Vauclin (larvae) [28]; D, Vauclin (males+females) [28]; E, PMDR (females) [30]; F, IM (males+females) [30]; G, IM (larvae) [30]; H, Iquitos (males+females) [56]; I, Calderitas (males+females) [56]; J, Lazaro C. (males+females) [56]; K, Merida (males+females) [56]; and L, Noexp-Perm (larvae) [58].